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Medical News Today: Melatonin: Is it safe for babies?

Melatonin is a hormone that helps regulate the body’s sleep-wake cycle. While melatonin is safe in the short term for most adults, many wonder whether they can give melatonin to babies and children who are having trouble sleeping.

Although the body produces its own melatonin, taking melatonin supplements can help provide short-term treatment of insomnia and other sleep-related disorders.

It is important to note that the Food and Drug Administration (FDA) do not regulate supplements, including melatonin, in the same way as drugs. This means that the FDA do not review whether a supplement is safe or effective before it arrives on store shelves.

The National Institutes of Health (NIH) report that most adults can safely use melatonin for short periods. However, healthcare providers are unsure of the long-term effects of regular melatonin use.

Below, learn whether any research supports the use of melatonin in babies and children. We also describe how melatonin works, associated risks, and alternative ways to encourage sleep.

a woman taking her baby to a doctor to ask if it's ok to give melatonin to babiesShare on Pinterest
Talk to a doctor if a baby is having difficulty sleeping.

Researchers have not yet determined whether it is safe to use melatonin to treat sleep issues in babies.

Newborns produce extremely low levels of melatonin, and production increases with age. Most infants establish clear circadian rhythms 6–18 weeks after birth.

Circadian rhythms are patterns of behavioral change that follow a daily cycle. They make up what a person might call their “internal clock.”

The Centers for Disease Control and Prevention (CDC) recommend that infants aged 4–12 months get a total of 12–16 hours of sleep every 24 hours.

No research has established the safety of melatonin use in healthy babies.

Speak with a pediatrician or sleep specialist if a baby is not getting enough sleep. Do not give melatonin to a baby unless a doctor or another healthcare professional has advised it.

Up to 25% of healthy children and 75% of children with neurodevelopmental or psychological conditions experience insomnia, according to the authors of one 2016 investigation.

Melatonin may help treat insomnia in children when behavioral and lifestyle adjustments do not work.

In one 2010 study, involving 72 children with chronic insomnia, researchers found that melatonin reduced the time that it took for the children to fall asleep by 35 minutes, compared with a placebo — treatment with no active ingredient.

However, the authors reported the following side effects of the treatment:

  • redness of the cheeks, earlobes, and eyes 1 hour after taking melatonin
  • dizziness
  • feeling cold
  • a headache
  • a stomachache
  • nausea

The findings of a 2017 study suggest that melatonin is slightly more effective than light therapy at treating insomnia in children.

Low dosages of melatonin appear to be safe for children. Authors of a 2019 review looked at investigations into the use of melatonin in kids with insomnia or other sleep disturbances. They found that effective dosages ranged from 1.0 to 7.5 milligrams (mg) and that side effects were similar to those reported elsewhere.

Still, available evidence is limited — there is a lack of large studies and long-term research into the effects of melatonin in kids. Before giving this supplement to children, discuss other options with a pediatrician.

Read more about melatonin use in children here.

The body releases melatonin as part of the processes that support the circadian rhythm.

The hypothalamus is a small area at the base of the brain near the pituitary gland. This area contains the suprachiasmatic nucleus (SCN), which is the primary regulator of the circadian rhythm.

The SCN maintains this rhythm in response to changing sunlight levels in each 24-hour period. At dawn, for example, it stimulates the release of various hormones that prepare the body for waking.

When the sun sets and light levels begin to decrease, the SCN prepares the body for sleep by signaling the pineal gland to release melatonin.

Some people refer to melatonin as the “hormone of darkness” because the pineal gland releases it in the evening. Exposure to light inhibits this process.

Melatonin affects numerous bodily functions, such as:

  • blood pressure
  • immune function
  • metabolism
  • digestion
  • bone formation
  • reproduction

If a child’s pineal gland does not secrete enough melatonin at night, they may develop insomnia or delayed sleep phase disorder. This condition extends wakefulness at nighttime, even when a person feels tired, and it often appears during teenage years.

Here, find 21 evidence-based ways to help a person fall asleep.

According to the CDC, children taking melatonin should do so about 30 minutes before bedtime. Controlled-release versions of melatonin may work better for children who have difficulty staying asleep.

Melatonin usually comes in pill form. However, for children who have difficulty swallowing tablets, liquids, dissolvable strips, and gummies are available.

The American Academy of Pediatrics recommend starting with the lowest dosage suggested on packaging. A dose as low as 0.5 mg or 1 mg may be effective in many children.

Before giving a child any form of melatonin, however, speak with a doctor. They can recommend the best dosage and schedule.

The authors of one 2019 article report that melatonin is relatively safe and presents a low risk of side effects — in general, not necessarily in children.

In a 2018 study, researchers attempted to observe the longer-term effects of melatonin in 33 people who had started taking the supplement for chronic insomnia as children.

The participants were 6–12 years old when they began the treatment, and they continued to take melatonin for an average of 10.8 years.

Over a third of the group reported having difficulty falling asleep after discontinuing melatonin treatment. Another third reported having one or more headaches at least once a month while taking the supplement.

In addition to headaches, other potential side effects of melatonin include:

  • restless legs
  • drowsiness
  • nausea

Some parents of participants felt that their child had started puberty earlier or later than most of their peers.

It is important to note that the study above is an exception — most investigations into melatonin use in children have been short-term.

Parents and caregivers may want to try behavioral and lifestyle adjustments before giving a child melatonin.

The following can help a person fall asleep earlier and stay asleep longer:

  • going to bed and waking up at the same times, even on weekends
  • avoiding naps during the day
  • getting enough physical exercise each day
  • eating dinner at least 2 hours before bedtime
  • keeping the bedroom quiet, dark, and cool
  • avoiding stimulants, such as caffeine and sugar, before bedtime
  • avoiding looking at screens — of televisions and computers, for example — at least 1 hour before bedtime

If a child’s sleep problems persist after trying the modifications above, it may be a good idea to consult a pediatrician or sleep specialist.

Can certain foods help encourage healthy sleep? Learn more here.

Melatonin is a hormone that helps support the body’s circadian rhythm.

If a child has a disrupted sleep-wake cycle or if their pineal gland does not secrete enough melatonin, they may develop insomnia or another sleep disorder.

Keeping a consistent bedtime routine that includes limiting the use of electronic devices and avoiding stimulants, such as caffeine, can help relieve insomnia in some children.

If a child’s sleeping habits do not improve with these and other behavioral modifications, it may be a good idea to speak with a pediatrician about treatment options, including melatonin.

Melatonin seems to help correct a child’s sleep cycle in the short term. However, no evidence supports its use in babies, and the long-term effects in children remain unclear.


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